Tree Hill bids goodbye to the past while anticipating the future: Lucas and Peyton prepare for the birth of their child with the help of a surprise visitor, Dan nears his end, and Brooke works with Victoria to relaunch Clothes Over Bro's. Meanwhile, Nathan returns to Tree Hill to face Haley and Jamie after being released from the Chiefs.
Lucas and Peyton's wedding day finally arrives, bringing some surprise guests along with it. Haley finds herself playing an unexpected role in the ceremony, as Skills and Brooke try to control Jamie and Nick. Meanwhile, Nathan continues to hope to be drafted into the NBA.
The families of Tree Hill draw closer as Lucas bonds with Jamie while working on Peyton's car, Sam develops a connection with Victoria, and Brooke and Haley throw Peyton a baby shower. Meanwhile, Nathan's ambitions seem closer than ever when he learns that an NBA scout will be watching his next game.
Nathan and Haley both face their dreams as he questions his ambition to play in the NBA and she receives an offer from Nick Lachey. Meanwhile, Brooke learns something that could change Sam's life forever, Jamie attends his first school dance, and Lucas and Peyton take a road trip.
The parents of Tree Hill face difficult challenges: Lucas finds himself fighting to stay calm when Peyton's pregnancy faces further problems, Nathan and Haley clash over the decision to pull Jamie out of school, and Victoria returns to tempt Brooke back into the business. Meanwhile, Mouth continues to mend his relationship with Millie.
Everyone seems to be going somewhere: Lucas takes Nathan and Jamie to a place from his past, and Mouth and Skills go on a road trip. Back in Tree Hill, Brooke faces a tough choice when Julian makes her a startling offer. Meanwhile, Sam and Jack fight to get Haley's job back, and Peyton prepares for her future.
The production of the film continues to prove challenging as Lucas and Julian face yet another obstacle. Mia also struggles with creative difficulties as she develops her new song, leading Peyton and Haley to try and help her. The kids of Tree Hill confront their own problems when Jamie finds out the truth about Dan and Sam is arrested.
Tree Hill's romances face more trials: Peyton and Lucas receive shocking news about the pregnancy, Brooke's relationship with Julian comes to a crossroads, and Mouth and Millie try to pick up the pieces and move on. Meanwhile, Jamie spends the night with his grandparents while Nathan and Haley celebrate their anniversary.
As Peyton begins to plan the wedding, Lucas attempts to put a cast together for his movie. Meanwhile, Haley is faced with a difficult decision, and Nathan gets great news.
Lucas and Julian have problems selecting a director for their film. Elsewhere, Peyton is unsure of how she feels about a present Lucas gave her, and Brooke faces romantic troubles.